CARCINOMA UROTELIAL EM VESÍCULA URINÁRIA EM CÃO: RELATO DE CASO

Abstract

Urothelial carcinoma in the urinary bladder in dogs is a neoplasm characterized by its invasive and metastatic nature, and may be associated with obstructive conditions in the region of the bladder trigone, leading to death of the animal due to impaired renal function. The etiology is not fully understood, but it is suspected that prolonged contact of urine rich in tryptophan with the bladder mucosa may predispose to the emergence of TCC. Among the breeds, the Scottish Terrier stands out as the most predisposed, presenting a risk more than 20 times higher than other breeds for development. Diagnosis can be made through physical examination, hematological, biochemical and imaging tests, urinalysis, and cytological and molecular evaluation of the bladder lavage; however, the definitive diagnosis is through histopathological analysis of the fragment. The treatment includes the use of a COX-2 inhibitor, such as piroxicam, in combination with antineoplastic chemotherapy and, if possible, surgical resection of the neoplasm. There is no curative therapy for this disease yet, but it is expected to improve the animal's quality of life and also increase its survival time. Therefore, the objective of this study is to report the clinical case of a 14-year-old male dog, mixed breed (SRD), with ultrasound findings consistent with ureteral obstruction, which underwent surgery with the technique of sectioning the ureters, reimplantation in the urinary bladder by microscopy and implantation of a bilateral double-J ureteral stent in order to reestablish urinary flow associated with a biopsy of the tumor. Unfortunately, after the procedure, the elderly animal experienced a worsening of concomitant Chronic Kidney Disease (CKD) and ended up dying.