SÍNTESE E CARACTERIZAÇÃO DO COMPLEXO DE ZINCO COM O LIGANTE N,N-(dimetil)-N’-benzoiltioureia

Abstract

The use of coordination compounds in medicine has proven to be an area of great scientific interest, mainly due to the many achievements from the use of this class of compounds. As an example, one can cite the revolution in cancer therapy promoted by the incorporation of the metallodrug widely known as cisplatin in the treatment of the disease. Currently, many other metallic compounds are used, which allows exploring the properties of metals for the design of new metallopharmaceuticals. This work supervised the synthesis and characterization of a zinc complex with the acylthiourea ligand, which is recognized for its biological applicability and, in addition, in the field of inorganic chemistry, it acts as a very universal ligand, presenting different coordination centers. The proposed compound was synthesized and characterized mainly by the spectroscopic technique of Nuclear Magnetic Resonance (1H, 13C, COSY, HSQC and HMBC) and by X-Ray Diffraction for structural determination. The complex was obtained through bidentate anionic coordination of the ligand, via the sulfur and oxygen atoms, being stabilized by a six-membered ring. In addition, the baseline of the NMR spectra showed that the compound presented a considerable purity, in which, in the future, it will contribute to the performance of biological studies.