SÍNTESE, CARACTERIZAÇÃO E CITOTOXICIDADE DE COMPLETO ORGANOMETÁLICO DE RUTÊNIO COM LIGANTE ACILTIOUREIA DISSUBSTITUÍDO

Abstract

Medical Bioinorganic Chemistry is an area of science that understands the functions and applications of metallic compounds in biological systems as therapeutic agents, and has been establishing itself as a promising field of knowledge due to the effectiveness of using the cisplatin compound in the cancer treatment. Currently, the scientific area has driven the development of new metal ion based chemotherapy. The present research project proposes to obtain and characterize a new ruthenium complex with the acylthiourea ligand with possible promising cytotoxic activity. The compound was obtained and characterized using the Nuclear Magnetic Resonance technique of the atoms of 31P {1H}, 13C {1H} and 1H, as well as the two-dimensional techniques HMBC, HSQC and COZY. In addition to molar conductivity measurements. Performed the cytotoxic evaluation of the complex in the breast tumor lineage, MDA-MB-231. The data obtained indicate that the compound presents appreciable purity, where the assigned signals converge to the expected structure. Through these analyzes it is suggested that the ligand coordinates with the metal in a bidentate form, via S and O atoms. Through the cell proliferation assay, the compound demonstrated potential for applicability in the medicinal area, presenting an IC50 value similar to that of cisplatin and considerably less than the precursor and ligand, respectively.