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dc.contributor.advisor1Pinto, Guilherme Malafaia-
dc.contributor.advisor1Latteshttp://lattes.cnpq.br/7222293518573336pt_BR
dc.contributor.referee1Pinto, Guilherme Malafaia-
dc.contributor.referee1Latteshttp://lattes.cnpq.br/7222293518573336pt_BR
dc.contributor.referee2Menezes, Ivandilson Pessoa Pinto de-
dc.contributor.referee2Latteshttp://lattes.cnpq.br/3265810851746141pt_BR
dc.contributor.referee3Cunha, Ananda Helena Nunes-
dc.contributor.referee3Latteshttp://lattes.cnpq.br/4271625054527491pt_BR
dc.creatorSilva, Wellington Alves Mizael da-
dc.creator.Latteshttp://lattes.cnpq.br/9347336648372119pt_BR
dc.date.accessioned2019-01-31T18:04:49Z-
dc.date.available2018-03-13-
dc.date.available2019-01-31T18:04:49Z-
dc.date.issued2018-03-13-
dc.identifier.urihttps://repositorio.ifgoiano.edu.br/handle/prefix/208-
dc.description.abstractEffluents are highly polluting waste, which can have negative impacts on people's health and the environment. However, studies investigating the effects of dermal exposure to these pollutants on the central nervous system of experimental mammalian models are still incipient. In this sense, and in order to expand the knowledge beyond the neurotoxic effects observed when the water contaminated by these xenobiotics is ingested, the neurobehavioral effects of the dermal exposure of males from the C57Bl/6J and Swiss lineages were analyzed. The animals were exposed the crude effluent (wet blue type) for two hours for five days, totaling 15 days of exposure. Afterwards, the animals were submitted to the high cross maze (anxiety predictive test) and to the object recognition test (used to identify memory deficit). Our data showed that dermal exposure to tannery effluent induced an anxiogenic behavior in the animals, when compared to those that did not have direct contact with these pollutants. It was also observed that the animals exposed to the effluent of tannery obtained lower rates of recognition of new objects, evidencing the memory deficiency and indicating a possible influence of the constituents of the tannery effluent on animal cognition. The present study supports the hypothesis that dermal exposure to tannery effluents causes behavioral disturbances in C57Bl/6J and Swiss micept_BR
dc.description.resumoOs efluentes do curtume constituem resíduos altamente poluidores, o que pode causar impactos negativos para a saúde das pessoas e para o ambiente. Contudo, estudos que investigaram os efeitos da exposição dérmica a estes poluentes no sistema nervoso central dos modelos experimentais de mamíferos são ainda incipientes. Nesse sentido, e com o objetivo de expandir o conhecimento além dos efeitos neurotóxicos observados quando a água contaminada por esses xenobióticos é ingerida, foram analisados os efeitos neurocomportamentais da exposição dérmica de machos de camundongos das linhagens C57Bl/6J e Swiss. Os animais foram expostos ao efluente de curtume bruto (tipo wet blue) durante duas horas, durante cinco dias, totalizando 15 dias de exposição. Depois, os animais foram submetidos ao labirinto em cruz elevado (teste preditivo da ansiedade) e ao teste de reconhecimento de objeto (utilizado na identificação de déficit de memória). Nossos dados mostraram que a exposição dérmica ao efluente de curtume induziu um comportamento ansiogênico nos animais, quando comparados àqueles que não tiveram contato direto com esses poluentes. Observou-se também que os animais expostos ao efluente de curtume obtiveram menores índices de reconhecimento de novos objetos, evidenciando assim deficiência de memória e indicando uma possível influência dos constituintes do efluente de curtume na cognição animal. O presente estudo atesta a hipótese de que a exposição dérmica a efluentes de curtumes provoca distúrbios comportamentais em camundongos C57Bl/6J e Swiss.pt_BR
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dc.languageporpt_BR
dc.publisherInstituto Federal Goianopt_BR
dc.publisher.countryBrasilpt_BR
dc.publisher.departmentCampus Urutaípt_BR
dc.publisher.programPrograma de Pós-Graduação em Conservação de Recursos Naturais do Cerradopt_BR
dc.publisher.initialsIF Goianopt_BR
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dc.rightsAcesso Abertopt_BR
dc.subjectxenobióticospt_BR
dc.subjectmamíferos - modelos experimentaispt_BR
dc.subjectefluentes agroindústriaispt_BR
dc.subjectrecursos hídricos - sustentabilidadept_BR
dc.subjectefluentes - poluição - contaminaçãopt_BR
dc.subjectcamundongos Swisspt_BR
dc.subjectC57Bl/6Jpt_BR
dc.subjectáguas - poluentes - preservação ambientalpt_BR
dc.subject.cnpqCIENCIAS BIOLOGICASpt_BR
dc.titleALTERAÇÕES COMPORTAMENTAIS EM CAMUNDONGOS EXPOSTOS DERMICAMENTE A EFLUENTE DE CURTUMEpt_BR
dc.title.alternativeBehavioral Changes in Mice Exposed Dermically Tanning Effluentpt_BR
dc.typeDissertaçãopt_BR
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