ESTUDO DE ESPECTROSCOPIA NA REGIÃO DO INFRAVERMELHO DO LAPACHOL DA β-lapachona E DO HIDROXI-HIDROLAPACHOL

Abstract

The national territory has a wide variety of biomes, especially the cerrado, in an area that extends from Mato Grosso to Paraná. Tabebuia, from the order of the bignoniaceae, is a common tree in this biome and is characterized by forming trees from ten to twenty meters in height with showy flowering. Also known as Ipe, it presents compounds of medicinal interest due to the presence of chemical compounds present in the core of its trunk, such as anthraquinones, iridoids and naphthoquinones. Among these compounds, Lapachol and the derivatives β-lapachone and hydroxy-hydrolapachol are present in bioenergetic processes of respiration and photosynthesis, having the role of electron transporters between protein membranes. Its pharmacological properties have aroused interest in national and foreign researches of different synthesis and application, with proven studies of its action, anti-inflammatory, antifugic, anticancer, among others. In this sense, being aware of the various applicability of lapachol and its derivatives, the present work aimed to carry out its spectroscopic characterization by spectroscopy in the infrared region with Fourier transform (Fourier Transform Infrared – FTIR). The choice of these substances is linked to the line of research that has been developed by the research group of the Organic and Electroanalytical Laboratory (LOE), coordinated by Prof. Dr. Miqueias Ferreira Gomes, in which the work was developed.